Alpiptakem-T Injection (Vial) (Vial) Piperacillin 4 G + Tazobactam 0.5 G By Alkem

Composition

Piperacillin 4 g \+ Tazobactam 0.5 g.

This is a broad-spectrum penicillin antibiotic + beta-lactamase inhibitor combination, commonly supplied as a powder for IV injection/infusion.

- Piperacillin 4 g — kills susceptible bacteria by interfering with bacterial cell-wall formation.
- Tazobactam 0.5 g — inhibits certain beta-lactamase enzymes that can make bacteria resistant to piperacillin.

Uses

It is used for moderate to severe bacterial infections, particularly in hospital settings, including:

- Pneumonia, including hospital-acquired infections
- Complicated urinary tract infections
- Intra-abdominal infections
- Skin and soft-tissue infections
- Severe bloodstream infections
- Certain gynaecological infections
- Other infections caused by susceptible bacteria

It has activity against many Gram-positive, Gram-negative, and anaerobic bacteria, including _Pseudomonas aeruginosa_.

It does not treat viral infections such as influenza or the common cold.

How to Use

This medicine is administered intravenously by a healthcare professional.

The dose and dosing interval depend on the type and severity of infection, kidney function, age, and clinical response. Dose adjustment is usually required in significant kidney impairment.

Do not self-inject or alter the prescribed dose.

Precautions & Warnings

Tell your doctor if you have:

- Allergy to penicillins, cephalosporins, carbapenems, or other beta-lactam antibiotics
- Kidney disease
- Liver disease
- A history of seizures
- A history of severe antibiotic-associated diarrhoea or colitis
- A bleeding or clotting disorder

Piperacillin/tazobactam can occasionally affect kidney function, blood counts, electrolytes, and liver function, particularly during prolonged treatment.

Possible Side Effects

Common side effects include:

- Diarrhoea
- Nausea or vomiting
- Headache
- Injection-site reactions
- Skin rash

Seek urgent medical attention for difficulty breathing, facial/throat swelling, severe rash, seizures, persistent or bloody diarrhoea, unusual bleeding, or significantly reduced urine output.

Pregnancy & Breastfeeding

If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor. It may be used during pregnancy when the benefits of treating a significant bacterial infection outweigh potential risks.

Storage

Unopened vials should be stored according to the manufacturer's instructions. Reconstituted and diluted solutions have specific stability requirements and should be prepared and handled by healthcare professionals.

Important Safety Information

Piperacillin/tazobactam should be used only for an appropriate bacterial infection and under medical supervision. Kidney function and, when appropriate, blood counts and electrolytes may need monitoring. Tell your healthcare team about all medicines you take, especially anticoagulants, other antibiotics, or medicines that can affect kidney function.