AMPHOSURGE 50mg (Liposomal Amphotericin B Inj)

Composition
Each vial contains Liposomal Amphotericin B 50 mg formulated in a liposomal delivery system for intravenous infusion.

Description
Amphosurge 50 mg is a liposomal formulation of Amphotericin B used for the treatment of severe systemic fungal infections, including cryptococcosis, aspergillosis, mucormycosis, and visceral leishmaniasis. The liposomal carrier enhances tissue penetration and significantly reduces nephrotoxicity compared to conventional Amphotericin B. It works by binding to ergosterol in fungal cell membranes, causing increased permeability and cell death. This formulation provides better tolerability, improved safety, and targeted antifungal action in critically ill patients.

Adverse Effects
Common adverse effects include fever, chills, nausea, vomiting, headache, and infusion-related reactions. Less commonly, it may cause electrolyte disturbances such as hypokalemia and hypomagnesemia. Although reduced, nephrotoxicity may still occur, along with liver enzyme elevation or anemia in some patients.

Precautions
Administration should be supervised by experienced healthcare professionals in a hospital setting. Monitor renal function, liver enzymes, electrolytes, and complete blood count regularly during therapy. Infusion reactions may require premedication. Use with caution in patients with existing kidney impairment or those receiving nephrotoxic medications. Pregnancy use should be based on clinical necessity and physician judgment.

Storage
Store unopened vials below 25°C and protect from light. After reconstitution, use promptly or store as per manufacturer recommendations. Keep out of reach of children.