Dapaking Gm2 Xr Tablets (Glimepiride 2 mg + Metformin Hydrochloride 500 mg + Dapagliflozin 10 mg)

Composition:

Glimepiride 2 mg ,Metformin Hydrochloride (XR) 500 mg ,Dapagliflozin 10 mg
Therapeutic Class: Oral Antidiabetic (Triple Combination Therapy)

Description

Dapaking GM2 XR Tablet is a triple oral antidiabetic combination that provides comprehensive control of blood glucose in Type 2 Diabetes Mellitus (T2DM) through three distinct mechanisms:

Glimepiride: A sulfonylurea that stimulates pancreatic β-cells to release insulin.

Metformin XR: A biguanide that reduces hepatic glucose production and enhances insulin sensitivity.

Dapagliflozin: A SGLT2 inhibitor that lowers blood glucose by increasing renal glucose excretion and also offers cardiovascular and renal benefits.

This combination targets insulin secretion, insulin resistance, and glucose elimination, resulting in effective glycemic control with convenience of once-daily dosing.

Warnings and Precautions

Hypoglycemia: Risk due to Glimepiride; educate patient on recognition and management.

Lactic Acidosis: Associated with Metformin; avoid in renal impairment.

Genital/Urinary Tract Infections: Common with Dapagliflozin; maintain hygiene.

Volume Depletion: Monitor blood pressure and renal function in elderly and diuretic users.

Weight Loss and Dehydration: Monitor during therapy.

Adverse Effects

Common:

Hypoglycemia, nausea, diarrhea, headache, dizziness, genital infections, polyuria.

Serious (rare):

Lactic acidosis, severe hypoglycemia, dehydration, hypersensitivity reactions.

Pregnancy and Lactation

Pregnancy: Use only if clearly necessary; switch to insulin if required.

Lactation: Not recommended; discontinue drug or breastfeeding.

Storage

Store below 30°C, protected from moisture and light.

Keep out of reach of children.