Sitasure M 50 Forte Tablet (Sitagliptin 50 mg + Metformin 1000 mg)

Composition: Each film-coated tablet contains:

Sitagliptin 50 mg

Metformin Hydrochloride 1000 mg
Manufacturer: Alkem Laboratories Ltd.
Pack Size: 15 tablets

Description:

Sitasure M50 Forte is a fixed-dose oral antidiabetic combination containing Sitagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, and Metformin Hydrochloride, a biguanide.
It offers a dual mechanism of action to achieve comprehensive glycemic control in patients with type 2 diabetes mellitus (T2DM):

Sitagliptin enhances the body’s own incretin system by inhibiting DPP-4 enzyme, increasing levels of GLP-1 and GIP hormones. This promotes glucose-dependent insulin secretion and suppresses hepatic glucagon release.

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and enhances insulin sensitivity in peripheral tissues.

This combination helps control both fasting and postprandial blood glucose levels with a low risk of hypoglycemia.

Warnings & Precautions:

Monitor renal function before initiation and periodically thereafter.

Risk of lactic acidosis due to metformin — discontinue immediately if symptoms such as malaise, myalgia, respiratory distress, or abdominal discomfort occur.

Avoid alcohol to reduce lactic acidosis risk.

Sitagliptin may rarely cause pancreatitis or hypersensitivity reactions — discontinue if severe abdominal pain or allergic symptoms occur.

Discontinue temporarily during radiologic procedures using iodinated contrast media.

Not indicated for type 1 diabetes or diabetic ketoacidosis.

Adverse Effects:

Common: Nausea, diarrhea, abdominal discomfort, headache, upper respiratory infection

Less common: Dizziness, metallic taste, mild hypoglycemia (with insulin/sulfonylureas)

Rare: Lactic acidosis, pancreatitis, rash, hepatic enzyme elevation

Storage:

Store below 25°C, in a cool, dry place, protected from light and moisture.
Keep out of reach of children.